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<strong>&#12304;&#26680;&#24515;&#25552;&#31034;&#12305;</strong><P>&#22312;&#20998;&#23376;&#29983;&#29289;&#23398;&#30740;&#31350;&#20013;&#65292;&#20154;DNA&#19982;RNA&#26434;&#20132;&#29255;&#27573;&#20316;&#20026;&#19968;&#31181;&#29305;&#27530;&#30340;&#26680;&#37240;&#32467;&#26500;&#65292;&#27491;&#36880;&#28176;&#25581;&#31034;&#20854;&#22312;&#22522;&#22240;&#34920;&#36798;&#35843;&#25511;&#21644;&#30142;&#30149;&#26426;&#21046;&#20013;&#30340;&#37325;&#35201;&#24615;&#12290;&#36825;&#31181;&#26434;&#20132;&#29255;&#27573;&#30001;DNA&#21644;RNA&#38142;&#36890;&#36807;&#30897;&#22522;&#20114;&#34917;&#37197;&#23545;&#24418;&#25104;&#65292;&#24120;&#35265;&#20110;&#36716;&#24405;&#12289;&#21098;&#25509;&#21450;&#36870;&#36716;&#24405;&#31561;&#36807;&#31243;&#20013;&#65292;&#20026;&#29702;&#35299;&#20154;&#31867;&#22522;&#22240;&#32452;&#21151;&#33021;&#25552;&#20379;&#20102;&#26032;&#35270;&#35282;&#12290;</P><P>&#20154;DNA&#19982;RNA&#26434;&#20132;&#29255;&#27573;&#30340;&#26680;&#24515;&#29305;&#24449;&#21253;&#25324;&#65306;1. &#32467;&#26500;&#31283;&#23450;&#24615;&#65306;&#20381;&#36182;&#27682;&#38190;&#21644;&#30897;&#22522;&#37197;&#23545;&#32500;&#25345;&#65292;&#20294;&#30456;&#36739;&#20110;&#21452;&#38142;DNA&#26356;&#26131;&#21463;&#29615;&#22659;&#22240;&#32032;&#24433;&#21709;&#65307;2. &#21151;&#33021;&#22810;&#26679;&#24615;&#65306;&#21442;&#19982;&#22522;&#22240;&#27785;&#40664;&#12289;&#36716;&#24405;&#28608;&#27963;&#21450;&#22522;&#22240;&#32452;&#23436;&#25972;&#24615;&#32500;&#25252;&#65307;3. &#26816;&#27979;&#26041;&#27861;&#65306;&#22914;R-loop&#27979;&#24207;&#25110;&#20813;&#30123;&#27785;&#28096;&#25216;&#26415;&#21487;&#29305;&#24322;&#24615;&#35782;&#21035;&#36825;&#20123;&#29255;&#27573;&#12290;&#20197;&#19979;&#35814;&#32454;&#35828;&#26126;&#20854;&#24418;&#25104;&#26426;&#21046;&#19982;&#29983;&#29289;&#23398;&#24847;&#20041;&#12290;</P><P>&#24418;&#25104;&#36807;&#31243;&#36890;&#24120;&#22987;&#20110;RNA&#32858;&#21512;&#37238;&#22312;&#36716;&#24405;&#26102;&#19982;DNA&#27169;&#26495;&#38142;&#30701;&#26242;&#37197;&#23545;&#65292;&#25110;&#30001;&#21453;&#21521;&#36716;&#24405;&#37238;&#29983;&#25104;cDNA&#26102;&#20135;&#29983;&#12290;&#22312;R-loop&#32467;&#26500;&#20013;&#65292;RNA&#38142;&#20405;&#20837;&#21452;&#38142;DNA&#65292;&#21462;&#20195;&#19968;&#26465;DNA&#38142;&#24418;&#25104;&#26434;&#20132;&#20307;&#65292;&#24120;&#35265;&#20110;&#21551;&#21160;&#23376;&#21306;&#22495;&#12290;&#20363;&#22914;&#65292;&#22312;&#20154;&#31867;&#32454;&#32990;&#20013;&#65292;&#20154;DNA&#19982;RNA&#26434;&#20132;&#29255;&#27573;&#21487;&#35843;&#25511;&#30284;&#22522;&#22240;MYC&#30340;&#34920;&#36798;&#65292;&#36890;&#36807;&#31283;&#23450;&#26579;&#33394;&#36136;&#24320;&#25918;&#29366;&#24577;&#20419;&#36827;&#36716;&#24405;&#12290;&#27492;&#22806;&#65292;&#24322;&#24120;&#31215;&#32047;&#30340;&#26434;&#20132;&#29255;&#27573;&#19982;&#31070;&#32463;&#36864;&#34892;&#24615;&#30142;&#30149;&#30456;&#20851;&#65292;&#22914;&#32908;&#33806;&#32553;&#20391;&#32034;&#30828;&#21270;&#30151;&#20013;&#65292;TDP-43&#34507;&#30333;&#21151;&#33021;&#22833;&#35843;&#23548;&#33268;R-loop&#36807;&#24230;&#31283;&#23450;&#65292;&#24341;&#21457;DNA&#25439;&#20260;&#12290;</P><P>FAQ&#65306;1. &#20154;DNA&#19982;RNA&#26434;&#20132;&#29255;&#27573;&#22914;&#20309;&#24433;&#21709;&#22522;&#22240;&#34920;&#36798;&#65311;&#31572;&#65306;&#23427;&#20204;&#36890;&#36807;&#20419;&#36827;&#25110;&#38459;&#30861;RNA&#32858;&#21512;&#37238;&#32467;&#21512;&#65292;&#35843;&#25511;&#36716;&#24405;&#36215;&#22987;&#21644;&#24310;&#20280;&#65292;&#21516;&#26102;&#24433;&#21709;&#21098;&#25509;&#20307;&#23545;&#21069;&#20307;mRNA&#30340;&#21152;&#24037;&#12290;2. &#26816;&#27979;&#36825;&#20123;&#29255;&#27573;&#26377;&#21738;&#20123;&#25216;&#26415;&#65311;&#31572;&#65306;&#24120;&#29992;&#26041;&#27861;&#21253;&#25324;DNA-RNA&#20813;&#30123;&#27785;&#28096;&#65288;DRIP&#65289;&#32467;&#21512;&#27979;&#24207;&#65292;&#25110;&#20351;&#29992;RNase H&#37238;&#28040;&#21270;&#21518;&#23545;&#27604;&#20998;&#26512;&#12290;3. &#23427;&#20204;&#19982;&#30284;&#30151;&#26377;&#20309;&#20851;&#32852;&#65311;&#31572;&#65306;&#22312;&#20083;&#33146;&#30284;&#21644;&#32467;&#32928;&#30284;&#20013;&#65292;&#26434;&#20132;&#29255;&#27573;&#24322;&#24120;&#31215;&#32047;&#21487;&#35825;&#23548;&#22522;&#22240;&#32452;&#19981;&#31283;&#23450;&#24615;&#65292;&#20419;&#36827;&#32959;&#30244;&#36827;&#23637;&#12290;4. &#26410;&#26469;&#30740;&#31350;&#26041;&#21521;&#26159;&#20160;&#20040;&#65311;&#31572;&#65306;&#24320;&#21457;&#38774;&#21521;&#36825;&#20123;&#32467;&#26500;&#30340;&#33647;&#29289;&#21487;&#33021;&#20026;&#27835;&#30103;&#36951;&#20256;&#30142;&#30149;&#25552;&#20379;&#26032;&#36884;&#24452;&#65292;&#20294;&#38656;&#24179;&#34913;&#27491;&#24120;&#19982;&#30149;&#29702;&#24615;&#21151;&#33021;&#12290;</P><P>&#24635;&#32467;&#32780;&#35328;&#65292;&#20154;DNA&#19982;RNA&#26434;&#20132;&#29255;&#27573;&#19981;&#20165;&#26159;&#22522;&#30784;&#30740;&#31350;&#30340;&#28966;&#28857;&#65292;&#20063;&#20026;&#30142;&#30149;&#35786;&#26029;&#21644;&#27835;&#30103;&#24102;&#26469;&#26032;&#24605;&#36335;&#12290;&#26410;&#26469;&#36890;&#36807;&#20248;&#21270;&#26816;&#27979;&#25216;&#26415;&#65292;&#31185;&#23398;&#23478;&#33021;&#26356;&#20840;&#38754;&#35299;&#26512;&#20854;&#22312;&#20154;&#31867;&#20581;&#24247;&#20013;&#30340;&#21452;&#37325;&#35282;&#33394;&#65292;&#25512;&#21160;&#20010;&#24615;&#21270;&#21307;&#23398;&#21457;&#23637;&#12290;</P>

&#30456;&#20851;&#20851;&#38190;&#35789;&#65306;DNA-RNA&#26434;&#21512;&#20307;&#21151;&#33021;&#12289;R-loop&#19982;&#22522;&#22240;&#35843;&#25511;&#12289;&#26680;&#37240;&#26434;&#20132;&#26816;&#27979;&#25216;&#26415;&#12289;&#36716;&#24405;&#22797;&#21512;&#20307;&#31283;&#23450;&#24615;&#12289;&#22522;&#22240;&#32452;&#19981;&#31283;&#23450;&#24615;&#26426;&#21046;
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